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Current pharmacological treatments for bone cancers like multiple myeloma have proven ineffective at healing bones or regenerating bone tissue. In this video, FRANZISKA JUNDT explores the extent to which physical stimuli and physical activity could represent effective treatment strategies for such conditions. Jundt explains how work with mice infected with tumor cells was followed up by a pilot clinical study on patients with a precursor condition to multiple myeloma, monoclonal gammopathy of undetermined significance. The work demonstrates that physical stimuli can have anti-tumor effects and it provides a scientific basis for a targeted use of sports against bone cancer. Ongoing research will analyze how physical activity has an effect on bone at the genetic level.


Franziska Jundt is Professor of Hematology and Internal Oncology at Julius-Maximilians-University in Würzburg. She is also a senior physician and leader of the Autologous Stem Cell Transplant division at the University Hospital, Würzburg. In addition, she leads the Multiple Myeloma Center at the Referenzzentrum Nordbayern and the research group Molecular Targeted Therapies in Lymphoma at the Comprehensive Cancer Center. Having studied in Boston and San Francisco, Jundt received her M.D. from Nobel Laureate Harald zur Hausen at the German Cancer Research Center in Heidelberg. Key foci in Jundt’s research and clinical practice include stem cell transplantation, bone regeneration and multiple myeloma. Having won Berlin Charité’s research prize in 2002, Jundt is currently part of the Women’s Leadership Program at the University of Würzburg.


University of Würzburg (Julius-Maximilians-Universität Würzburg)

"True to its motto ‘Science for Society’, the Julius-Maximilians-Universität Würzburg (JMU) - founded 1402 - is committed to advancing research in a wide range of disciplines. Academic rankings confirm the JMU’s place among the world’s high-performing research universities. Currently, the JMU has about 29.000 students who are enrolled in ten faculties. Its academic and administrative staff comprises more than 4.000 people. Approximately 420 professors are active in research and teaching at the university and the university hospital.
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Original publication

Mechanical Loading Prevents Bone Destruction and Exerts Anti-Tumor Effects in the MOPC315.BM.Luc Model of Myeloma Bone Disease

Bouchard Alice L., Brandl Andreas, Duda Georg N., Bogen Bjarne, Beilhack Andreas, Lynch Maureen E., Rummler* Maximilian, Ziouti* Fani, Jundt* Franziska and Willie* Bettina M.
(*These authors contributed equally) Acta Biomaterialia.
Published in 2020

Impact of Whole-Body Vibration Exercise on Physical Performance and Bone Turnover in Patients with Monoclonal Gammopathy of Undetermined Significance

Jundt Franziska, Seefried Lothar, Genest Franca, Strömsdörfer Johanna, Engelmann Bernhard, Lapa Constantin, Jakob Franz, Baumann Freerk T. and Sperlich Billy
Journal of Bone Oncology
Published in 2020